CYP2A6 Genetic Variation Alters Striatal-Cingulate Circuits, Network Hubs, and Executive Processing in Smokers
نویسندگان
چکیده
منابع مشابه
UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in european and african american smokers.
BACKGROUND Identifying sources of variation in the nicotine and nitrosamine metabolic inactivation pathways is important to understanding the relationship between smoking and cancer risk. Numerous UGT1A and UGT2B enzymes are implicated in nicotine and nitrosamine metabolism in vitro; however, little is known about their roles in vivo. METHODS Within UGT1A1, UGT1A4, UGT1A9, UGT2B7, UGT2B10, an...
متن کاملNetwork Hubs Buffer Environmental Variation in Saccharomyces cerevisiae
Regulatory and developmental systems produce phenotypes that are robust to environmental and genetic variation. A gene product that normally contributes to this robustness is termed a phenotypic capacitor. When a phenotypic capacitor fails, for example when challenged by a harsh environment or mutation, the system becomes less robust and thus produces greater phenotypic variation. A functional ...
متن کاملPM303. Altered temporo-striatal and fronto-cingulate circuits in acute methamphetamine nonhuman primate model
Alcoholism is a chronic, progressing, and relapsing psychiatric disorder with a substantial genetic background. The neural circuitry mediating alcohol reinforcement, seeking, and relapse has not been fully delineated. The aim of the present experiments was to acquire further insight into the neural systems associated with alcohol preference and high voluntary alcohol drinking in the alcohol-pre...
متن کاملVariation in CYP2A6 Activity and Personalized Medicine
The cytochrome P450 2A6 (CYP2A6) enzyme metabolizes several clinically relevant substrates, including nicotine-the primary psychoactive component in cigarette smoke. The gene that encodes the CYP2A6 enzyme is highly polymorphic, resulting in extensive interindividual variation in CYP2A6 enzyme activity and the rate of metabolism of nicotine and other CYP2A6 substrates including cotinine, tegafu...
متن کاملGenetic polymorphism of CYP2A6 gene and tobacco-induced lung cancer risk in male smokers.
Cytochrome P450 2A6 (CYP2A6) is the principal enzyme involved in the metabolic activation of tobacco-specific nitrosamines to their ultimate carcinogenic forms and metabolism of nicotine. We investigated the effects of the CYP2A6*4, an entire CYP2A6 gene deletion-type polymorphism, on lung cancer risk and daily cigarette consumption in Japanese male smokers via a hospital-based case control stu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2017
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2016.09.013